Fortune on Monday released its 68th annual ranked list of the 500 companies that generated the most revenue in the previous fiscal year. Several health systems—as well as many other companies in the health care industry—made the list.

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About the list

Fortune compiled the list based on the total revenues of for-profit companies for their 2021 fiscal years. To be eligible for the list, companies must have filed financial documents with a state or federal agency.

This year's Fortune 500 companies generated a record $16.1 trillion in revenue and $1.8 trillion in profits despite challenges from rising inflation, supply chain issues, and the ongoing Covid-19 pandemic.

For the list, Fortune sorted companies based on their sector. Within the health care sector, Fortune sorted companies based on different health care industries, including wholesalers, insurance and managed care, medical products and equipment, and pharmaceuticals.  

Notably, many health systems are organized as nonprofits, which are not eligible for inclusion on the Fortune 500 list.

Health care companies on the Fortune 500 list 

The five medical facilities on this year's top 500 list are:

62. HCA Healthcare (Nashville, TN)

181. Tenet Healthcare (Dallas, TX)

297. Universal Health Services (King of Prussia, PA)

304. Community Health Systems (Franklin, TN)

323. DaVita (Denver, CO)

The list also includes five health insurance companies:

5. United Health Group (Minnetonka, MN)

20. Anthem (Indianapolis, IN)

26. Centene (St. Louis, MO)

40. Humana (Louisville, KY)

125. Molina Healthcare (Long Beach, CA)

(Daily Briefing is published by Advisory Board, a division of Optum, which is a wholly owned subsidiary of UnitedHealth Group.)

Fourteen pharmaceutical companies made the list:

37. Johnson & Johnson (New Brunswick, NJ)

43. Pfizer (New York, NY)

63. AbbVie (North Chicago, IL)

71. Merck (Readington, NJ)

82. Bristol-Myers Squibb (New York, NY)

122. Eli Lilly (Indianapolis, IN)

129. Gilead Sciences (Foster City, CA)

140. Amgen (Thousand Oaks, CA)

195. Moderna (Cambridge, MA)

204. Viatris (Canonsburg, PA)

231. Regeneron Pharmaceuticals (Tarrytown, NY)

338. Biogen (Cambridge, MA)

440. Zoetis (Parsippany-Troy Hills, NJ)

448. Vertex Pharmaceuticals (Boston, MA)

In addition, two health care companies in the food and drug store category made the list:

18. Walgreens Boots Alliance (Deerfield, IL)

148. Rite Aid (Camp Hill, PA)

Eight companies in the medical products and equipment sector made the list:

86. Abbott Laboratories (Chicago, IL)

102. 3M (Saint Paul, MN)

118. Danaher (District of Columbia)

173. Beckton Dickinson (Franklin Lakes, NJ)

214. Stryker (Kalamazoo, MI)

292. Baxter International (Deerfield, IL)

319. Boston Scientific (Marlborough, MA)

438. Zimmer Biomet Holdings (Warsaw, IN)

Five pharmacy and other health care service companies made the list:

4. CVS Health (Woonsocket, RI)

12. Cigna (Bloomfield, CT)

230. Laboratory Corp. of America (Burlington, NC)

269. IQVIA Holdings (Durham, NC)

342. Quest Diagnostics (Secaucus, NJ)

The list also included five wholesalers within the health care industry:

9. McKesson (Irving, TX)

10. AmerisourceBergen (Conshohocken, PA)

15. Cardinal Health (Dublin, OH)

299. Henry Schein (Melville, NY)

361. Owens & Minor (Mechanicsville, VA)

And two scientific equipment companies:

92. Thermo Fisher Scientific (Waltham, MA)

457. Avantor (Radnor Township, PA)

(Fortune 500 list, 5/23; Fortune 500 methodology, accessed 5/24)